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位置: 首页> 品牌> Sigma-Aldrich> (Z)-Endoxifen

(Z)-Endoxifen

品牌
Sigma-Aldrich
货号
SML2368
规格纯度
≥98% (HPLC)
价格
1896.25 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
(Z)-Endoxifen
N-Desmethyl-4-hydroxytamoxifen
Metabolite BX
4-Hydroxy-N-desmethyl-tamoxifen
Endoxifen
Z-Endoxifen
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

(Z)-Endoxifen has been used to demonstrate the lack of contribution of subventricular zone and leptomeningeal cells in a study determining the generation of neuroblasts from astrocytes.

生化/生理作用

(Z)-Endoxifen (endoxifen) is an active tamoxifen metabolite generated via actions of cytochrome P450 (CYP) enzymes CYP3A4/5 and CYP2D6. Endoxifen is more potent than tamoxifen as a selective estrogen receptor modulator (SERM) bothin vitroandin vivowith good pharmacokinetics and oral availability (~80% MCF-7 tumor growth inhibition with 4-8 mg/kg/day endoxifen or 20 mg/kg/day tamoxifen in mice via p.o.). Endoxifen also exhibits 4-fold higher PKC inhibitory potency than tamoxifen and can overcome tamoxifen resistance due to cytochrome CYP2D6 polymorphism.

基本信息

经验(实验)分子式 C25H27NO2
分子量 373.49
MDL编号 MFCD09840374

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃

安全信息

象形图 GHS09
警示用语: Warning
危险声明 H400
预防措施声明 P273 - P391 - P501
危险分类 Aquatic Acute 1
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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