(R,S)-AM1241

半岛bd体育手机客户端 说明

应用

(R,S)-AM1241 has been used as a cannabinoid CB2 agonist:

• to study its inhibitory effect on bone cancer-induced pain and bone loss
• to study the effect of its interaction with 17βestradiol on proliferation activity in primary human osteoblasts
• to evaluate the sites of CB2 mediated antinociceptionin vivo.

包装

5, 25 mg in glass bottle

生化/生理作用

AM1241 acts as an antinociceptive agent in several animal pain models. It has a potential to delay disease progression in amyotrophic lateral sclerosis (ALS) mouse model. Intrathecal, intravenous or intraperitoneal administration of AM1241 reduces hyperalgesia and allodynia in neuropathic rats.
Selective CB₂cannabinoid receptor agonist

基本信息

经验(实验)分子式	C22H22IN3O3
分子量	503.33
MDL编号	MFCD11045986
PubChem化学物质编号	24891092
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
drug control	regulated under CDSA - not available from sigma-aldrich Canada
颜色	yellow
溶解性	DMSO: ~18 mg/mL at 60 ℃
SMILES string	CN1CCCCC1Cn2cc(C(=O)c3cc(ccc3I)[N+]([O-])=O)c4ccccc24
InChI	1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
InChI key	ZUHIXXCLLBMBDW-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H315 - H319 - H334 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves