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Z-Pro-prolinal

Z-脯氨酸

品牌
Sigma-Aldrich
CAS
88795-32-8
货号
SML0205
规格纯度
≥98% (HPLC)
价格
1148.45 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
88795-32-8
Z-Pro-prolinal
Phenylmethyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
ZPP
Cbz-Pro-Prolinal
Z-pro-pro-CHO
Z-prolyl-prolinal
Z-Pro-Pro-CHO, Z-PP-CHO
N-Benzyloxycarbonyl-L-prolyl-L-prolinal
Z-脯氨酸
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Z-Pro-prolinal was used to inhibit activation of rekallikrein in Prolylcarboxypeptidase assay in HUVECs. ZPP was also used in assays to identify enzymes important in the processing of angiotensin peptides in human glomerular endothelial cells.

包装

5, 25 mg in glass bottle

生化/生理作用

Z-Pro-prolinal is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = 1 nM.

POP has been connected to memory and mood through regulation of the brain levels of its peptide substrates, which include AVP, substance P, neurotensin and TRH and is a potential target in cognitive function, memory, and neurodegenerative disorders such as amnesia, Alzheimer′s disease, and depression. POP has recently been reported to be involved in the release of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) from its precursor, 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

基本信息

经验(实验)分子式 C18H22N2O4
分子量 330.38
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to tan
溶解性 DMSO: ≥10 mg/mL
储存温度 ?20℃
InChI 1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1
InChI key ORZXYSPOAVJYRU-HOTGVXAUSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302 - H319
预防措施声明 P301 + P312 + P330 - P305 + P351 + P338
危险分类 Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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