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UCSF924

品牌
Sigma-Aldrich
CAS
1434515-70-4
货号
SML2022
规格纯度
≥98% (HPLC)
价格
1318.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
1434515-70-4
UCSF924
6-Methyl-2-((3-phenoxypropylamino)methyl)quinolin-4(1H)-one
ZINC000091726127
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

UCSF924 (Compound 9-6-24; ZINC000091726127) is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC (Comound 9-6-16; ZINC000091707446) is the recommended negative control compound with a 1/2500-fold reduced D4 affinity.

基本信息

经验(实验)分子式 C20H22N2O2
分子量 322.40
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 ?20℃
SMILES string CC1=CC=C(NC(CNCCCOC2=CC=CC=C2)=CC3=O)C3=C1

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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