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Tonabersat

品牌
Sigma-Aldrich
CAS
175013-84-0
货号
SML1354
规格纯度
≥98% (HPLC)
价格
1827.35 *本价格含增值税费
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半岛bd体育手机客户端 名称:
175013-84-0
Tonabersat
(3S-cis)-N-(6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-chloro-4-fluoro-benzamide
SB 220453
SB-220453
N-[(3S,4S)-6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-3-chloro-4-fluoro-benzamide
半岛bd体育手机客户端 介绍:

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包装

5, 25 mg in glass bottle

生化/生理作用

Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.

基本信息

经验(实验)分子式 C20H19ClFNO4
分子量 391.82
MDL编号 MFCD00944458
PubChem化学物质编号 329825809
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
旋光性 [α]/D -100 to -110°, c = 1 in methanol
颜色 white to beige
溶解性 DMSO: 20 mg/mL, clear
储存温度 2-8℃
SMILES string CC(C1=CC=C2C([C@H](NC(C3=CC=C(F)C(Cl)=C3)=O)[C@H](O)C(C)(C)O2)=C1)=O
InChI 1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1
InChI key XLIIRNOPGJTBJD-ROUUACIJSA-N

安全信息

象形图 GHS07GHS09
警示用语: Warning
危险声明 H315 - H319 - H400
预防措施声明 P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
危险分类 Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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