半岛bd体育手机客户端 说明
生化/生理作用
TG4-155 is a brain penetrant prostaglandin EP2 specific antagonist. TG4-155 has a 4730X selectivity over EP4 (2.4 nM vs 11.4 mM in binding assays), and a 7 fold selectivity over DP1 receptors. TG4-155 crosses the blood brain barrier, and has no antagonistic effects on EP4 signaling, and displays neuroprotective effects in a pilocarpine-induced status epilepticus (SE) seizure model. TG4-155 does not interfere with G-protein function or phosphodiesterase activity, and does not inhibit COX-1 or COX-2.
基本信息
| 经验(实验)分子式 | C23H26N2O4 |
| 分子量 | 394.46 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 20 mg/mL, clear |
| 储存温度 | 2-8℃ |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P280 - P305 + P351 + P338 - P337 + P313 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
