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T863

品牌
Sigma-Aldrich
CAS
701232-20-4
货号
SML0539
规格纯度
≥98% (HPLC)
价格
1714.02 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
701232-20-4
T863
T-863
2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid
trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

  • to provide the opportunity to precisely control the DGAT inhibition
  • to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
  • to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
  • to block lipid droplet (LD) formation

包装

5, 25 mg in glass bottle

生化/生理作用

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

基本信息

经验(实验)分子式 C22H26N4O3
分子量 394.47
MDL编号 MFCD11977270
PubChem化学物质编号 329825541
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 15 mg/mL (clear solution)
储存温度 2-8℃
SMILES string CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
InChI 1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChI key FUIYMYNYUHVDPT-HDJSIYSDSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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