半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.
特点和优势
This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.
基本信息
| 经验(实验)分子式 | C6H11NO4 |
| 分子量 | 161.16 |
| MDL编号 | MFCD09836097 |
| PubChem化学物质编号 | 329826708 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 测定 | (single spot, TLC) |
| 质量水平 | 100 |
| 形式 | powder |
| 颜色 | white to off-white |
| 溶解性 | H2O: >1.5 mg/dL |
| 储存温度 | room temp |
| SMILES string | C[C@@H](CC(O)=O)[C@@H](N)C(O)=O |
| InChI | 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1 |
| InChI key | FHJNAFIJPFGZRI-WVZVXSGGSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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