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SR1848

品牌
Sigma-Aldrich
CAS
863588-32-3
货号
SML1513
规格纯度
≥98% (HPLC)
价格
1260.64 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
863588-32-3
SR1848
ML180
6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione
CDI 3238389
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

SR1848 has been used as a liver receptor homolog 1 (LRH-1) inhibitor to study the role of LRH-1 in the regulation of lipopolysaccharide (LPS)-induced proinflammatory cytokines in mice macrophage. It has also been used as an LRH-1 inhibitor to study its effects on activation-induced Fas ligand (FasL) expression in the murine T-cell hybridoma cell line.

包装

5, 25 mg in glass bottle

生化/生理作用

SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the expression of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm.
The actions of SR1848 might contribute to anti-cancer functionality.

基本信息

经验(实验)分子式 C20H25ClN4O2
分子量 388.89
MDL编号 MFCD05894342
PubChem化学物质编号 329825930

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 5 mg/mL, clear (warmed)
储存温度 2-8℃
SMILES string O=C(N(C1CCCCC1)C(N2)=O)C=C2N3CCN(C4=CC(Cl)=CC=C4)CC3
InChI 1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChI key CHMQQIFPOIZPIJ-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P301 + P312 + P330
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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