SMARt-420

品牌

Sigma-Aldrich

CAS

1616242-21-7

货号

SML2005

包装型号

规格纯度

≥98% (HPLC)

价格

1168.11 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

1616242-21-7
SMARt-420
1-Butanone, 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)
BDM41420
4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

SMARt-420 (Small Molecule Aborting Resistance) activates an alternative bioactivation pathway of the tuberculosis antibiotic pro-drug ethionamide. Ethionamide bioactivation is normally catalyzed by monooxygenase EthA, but mutations in the enzyme have allowed many strains to become resistant. SMARt-420 activates a previously unknown pathway, reversing ethionamide-acquired resistance and clearing ethionamide-resistant infection in mice in addition to increasing the sensitivity of bacteria to ethionamide.

基本信息

经验(实验)分子式	C₁₇H₁₉F₃N₂O₂
分子量	340.34
NACRES	NA.77

半岛bd体育手机客户端性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable