半岛bd体育手机客户端 说明
应用
SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease.
包装
5, 25 mg in glass bottle
生化/生理作用
SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon.
Nonpeptide, potent and selective endothelin converting enzyme inhibitor.
基本信息
| 经验(实验)分子式 | C18H13ClN5NaO3S · xH2O |
| 分子量 | 437.84 (anhydrous basis) |
| MDL编号 | MFCD06798351 |
| PubChem化学物质编号 | 329824532 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | off-white to light brown |
| 溶解性 | DMSO: ≥20 mg/mL H2O: ≥20 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1 |
| InChI | 1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1 |
| InChI key | HLHPDQXMLDUDQV-UHFFFAOYSA-M |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
