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位置: 首页> 品牌> Sigma-Aldrich> (1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N′-(1-pyridin-2-yl-ethylidene)-hydrazine

SI-2

品牌
Sigma-Aldrich
CAS
380537-35-9
货号
SML1762
规格纯度
≥98% (HPLC)
价格
1562.86 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
380537-35-9
SI-2
(1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone
(1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N′-(1-pyridin-2-yl-ethylidene)-hydrazine
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. conc. >/= 5 nM in cell-based SRC-1, SRC-2, and SRC-3 reporter assays) by downregulating SRCs protein, but not transcript level (Effec. conc. >/= 12.5 nM against SRC-3, >/= 25 nM against SRC-1 and SCR-2 in MDA-MB-468 culture). SI-2 is cytotoxic to breast cancer cultures (IC50= 1.5 nM/BT-474, 3.4 nM/MDA-MB-468, 22 nM/MCF-7), but not to normal hepatocytes even at 500 nM concentration. SI-2 is reported to be orally available in mice and, when administered intraperitoneally (2 mg/kg b.i.d.), effectively suppress MDA-MB-468-derived tumor expansion in mice in vivowith good pharmacokinetics (Cmax= 30 μM, tmax= 0.25 h, t1/2= 1.0 h; 20 mg/kg i.p.) and no apparent adverse effects to the animals.

基本信息

经验(实验)分子式 C15H15N5
分子量 265.31

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 , light yellow to dark orange
溶解性 DMSO: 20 mg/mL, clear
储存温度 2-8℃
SMILES string C/C(C1=CC=CC=N1)=N\NC2=NC3=C(C=CC=C3)N2C

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H315 - H319
预防措施声明 P305 + P351 + P338
危险分类 Eye Irrit. 2 - Skin Irrit. 2
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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