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SCIO-469

品牌
Sigma-Aldrich
CAS
309913-83-5
货号
SML3008
规格纯度
≥98% (HPLC)
价格
1272.2 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
309913-83-5
SCIO-469
6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-a-oxo-1H-indole-3-acetamide
2-(6-Chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide
SCIO469
Scios-469
Scios 469
Scios469
SCIO 469
Talmapimod
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

SCIO-469 (Talmapimod) is an orally active, potent and selective mitogen-activated protein kinase (MAPK) p38alpha (p38α, MAPK14) inhibitor (IC50 = 9 nM; 10-fold over p38β, >2000-fold over 20 other kinases) with no significant affinity toward a panel of 70 enzymes and receptors. SCIO-469 inhibits multiple myeloma (MM) growth in micein vivo(150 or 450 mg/kg powder diet; 5T2MM and 5T33MM) and augments proteasome inhibitor in a murine plasmacytoma model of MM (0.2 mg bortezomib/kg i.v. twice weekly with 30 mg SCIO-469/kg b.i.d. p.o.; RPMI8226).

基本信息

经验(实验)分子式 C27H30ClFN4O3
分子量 513.00
MDL编号 MFCD11973651

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string O=C(C(C1=CN(C2=C1C=C(C(Cl)=C2)C(N3[C@@H](CN([C@H](C3)C)CC4=CC=C(C=C4)F)C)=O)C)=O)N(C)C

Sigma-Aldrich

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