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SC75741

品牌
Sigma-Aldrich
CAS
913822-46-5
货号
SML2382
规格纯度
≥97% (HPLC)
价格
798.09 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
913822-46-5
SC75741
V1810
N-(6-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide
4SC-301
SC 75741
N-(5-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

SC75741 (4SC-301; V1810) is a potent NF-kappaB (NF-κB) inhibitor (IC50 = 200 nM against 10 ng/mL TNF-α-induced NF-κB reporter gene expression in A549 cells) that impairs p65 subunit (RelA) DNA-binding activity without affecting p65 phosphorylation or nuclear translocation, nor proteasome-mediated IκBα degradation. SC75741 induces apoptosis in multiple myeloma cultures (IC50 from 5 to 12 μM in 48 hrs; OPM2, U266, NCI-H929, RPMI-8226), but not PBMCs (89% viability post 4-hr 100 μM SC75741 treatment). NF-κB inhibition by SC75741 treatment is reported to effectively block influenza virus propagation both in culturesin vitro(1-5 μM) and in micein vivo(5 mg/kg daily i.v. or 7.5-15 mg/kg twice a day i.p.).

基本信息

经验(实验)分子式 C29H23N7O2S2
分子量 565.67

半岛bd体育手机客户端 性质

测定 ≥97% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string O=C(C1=CSC(C2CCN(C3=C4C(C=CS4)=NC=N3)CC2)=N1)NC5=NC6=CC(C(C7=CC=CC=C7)=O)=CC=C6N5

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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