SC-514

半岛bd体育手机客户端 说明

应用

SC-514 has been used to study its effect on lipopolysaccharide (LPS)-induced phosphorylation of NF-κB (nuclear factor-κB) p65 and p38 MAPK (mitogen-activated protein kinase).

包装

5, 25 mg in glass bottle

生化/生理作用

SC-514 is a cell-permeable, potent and selective ATP competitive inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) that specifically blocks NF-?B-dependent gene expression. SC-514 exhibits anti-inflammatory properties.
SC-514 is an amino-acetamide compound. It is selective for IKKβ with an IC50 value of 3?12 μM. SC-514 also inhibits cytokines such as interleukin-6 (IL-6) and IL-8, mediated by IKKβ. IKKβ is responsible for osteoclast survival, hence its inhibition affects osteogenesis.

基本信息

经验(实验)分子式	C9H8N2OS2
分子量	224.30
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	powder
颜色	white to light brown
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable