半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growthin vivoin an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.
基本信息
| 经验(实验)分子式 | C8H8Cl2N2S· HCl |
| 分子量 | 271.59 |
| MDL编号 | MFCD00035047 |
| PubChem化学物质编号 | 329823647 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white to off-white |
| 溶解性 | DMSO: >10 mg/mL H2O: >2 mg/mL |
| 储存温度 | room temp |
| SMILES string | Cl.NC(=N)SCc1ccc(Cl)cc1Cl |
| InChI | 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H |
| InChI key | COMNQRICZGJVLE-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
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