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Protein kinase Cα isozyme human

品牌
Sigma-Aldrich
货号
P1782
规格纯度
≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
价格
5881.15 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Protein kinase Cα isozyme human
PKCα
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.

单位定义

One unit will transfer 1 pmol of phosphate from ATP to Histone H1 in 1 minute at pH 7.4 at 30 ℃

外形

Supplied as a buffered aqueous glycerol solution, containing Trizma buffer, NaCl, DTT and Glutathione.

基本信息

MDL编号 MFCD00241710
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 200
重组 expressed in baculovirus infected insect cells
测定 ≥70% (SDS-PAGE)
形式 buffered aqueous glycerol solution
specific activity ≥250 units/μg protein
分子量 80-81 kDa by SDS-PAGE
UniProt登记号 P17252
运输 dry ice
储存温度 ?70℃
Gene Information human ... PRKCA(5578)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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