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位置: 首页> 品牌> Sigma-Aldrich> (βR,dR)-5-Cyclopropyl-2-(4-fluorophenyl)-4-[[[(3-fluorophenyl)methyl]amino]carbonyl]-β,d-dihydroxy-1H-imidazole-1-heptanoic acid

PF-03491165

(βR,dR)-5-Cyclopropyl-2-(4-fluorophenyl)-4-[[[(3-fluorophenyl)methyl]amino]carbonyl]-β,d-dihydroxy-1H-imidazole-1-heptanoic acid

品牌
Sigma-Aldrich
CAS
950741-95-4
货号
PZ0404
规格纯度
≥98% (HPLC)
价格
780.67 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
950741-95-4
PF-03491165
PF03491165
PF-03491165-00-0006
(βR,dR)-5-Cyclopropyl-2-(4-fluorophenyl)-4-[[[(3-fluorophenyl)methyl]amino]carbonyl]-β,d-dihydroxy-1H-imidazole-1-heptanoic acid
(3R,5R)-7-(4-((3-Fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid
(3R,5R)-7-(5-Cyclopropyl-4-(3-fluorobenzylcarbamoyl)-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid
PF 03491165
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

PF-03491165 is a potent HMG-CoA reductase inhibitor (IC50 = 0.1 nM) with good hepatoselectivity (rat hepatocyte/myocyte cholesterol synthesis IC50 = 0.1 nM/444 nM). PF-03491165 exhibits superior plasma low density lipoprotein (LDL)-lowering efficacy than rosuvastatin and pravastatin in Guinea pigs in vivo (EC50 = 5.9, 13.5, 73.3 mg/kg, respectively via daily po) despite its low oral bioavailability in rats and dogs.

基本信息

经验(实验)分子式 C27H29F2N3O5
分子量 513.53

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string FC1=CC=C(C=C1)C2=NC(C(NCC3=CC=CC(F)=C3)=O)=C(N2CC[C@H](C[C@H](CC(O)=O)O)O)C4CC4

Sigma-Aldrich

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