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位置: 首页> 品牌> Sigma-Aldrich> N-(3-Methylthiophene-2-carboxylic acid)-N′-[(3-hydroxy-2-naphthalenyl)methylene]hydrazide

PCNA-I1

品牌
Sigma-Aldrich
CAS
1364915-48-9
货号
SML0730
包装型号
规格纯度
≥98% (HPLC)
价格
1129.94 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1364915-48-9
PCNA-I1
N-(3-Methylthiophene-2-carboxylic acid)-N′-[(3-hydroxy-2-naphthalenyl)methylene]hydrazide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

PCNA-I1 is a small molecule PCNA inhibitor that selectively binds to PCNA trimers and reduces the association of PCNA with chromatin. PCNA-I1 induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells.
Proliferating cell nuclear antigen-l1 (PCNA) is a member of the scaffold B class. It acts as a linker at the monomer-monomer interface. PCNA-I1 has the ability to block the development of primary cultures of bone marrow mesenchymal stem cells, endothelial cells, lymphocytes, mammary epithelial cells and prostate epithelial cells.

基本信息

经验(实验)分子式 C17H14N2O2S
分子量 310.37
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 10 mg/mL, clear
储存温度 2-8℃

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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