半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
NSC23925 is a specific Pgp1 inhibitor. It reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 itself is not a substrate of Pgp1 but stimulates ATPase activity of Pgp, directly inhibiting the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1.
基本信息
经验(实验)分子式 | C22H24N2O2· 2HCl |
分子量 | 421.36 |
MDL编号 | MFCD22666390 |
PubChem化学物质编号 | 329825373 |
NACRES | NA.77 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
储存条件 | desiccated |
颜色 | white to beige |
溶解性 | H2O: 5 mg/mL (clear solution) |
储存温度 | room temp |
SMILES string | Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2 |
InChI | 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H |
InChI key | WGWOQHWZXLGPNG-UHFFFAOYSA-N |
安全信息
象形图 | |
警示用语: | Danger |
危险声明 | H301 |
预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
危险分类 | Acute Tox. 3 Oral |
储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |