半岛bd体育手机客户端 说明
生化/生理作用
MS417, a (+)-JQ1 analog, is a potent inhibitor of bromodomain-containing protein 4 (BRD4) that is highly specific for BRD4-BD1 and BRD4-BD2. MS417 binds with similar affinity to BRD4-BD1 and BRD4-BD2 (Kd =36.1, and 25.4 nM), while bulky tBu of JQ1 prevents tight binding to the cavity at BD1.
基本信息
经验(实验)分子式 | C20H19ClN4O2S |
分子量 | 414.91 |
MDL编号 | MFCD20526583 |
半岛bd体育手机客户端 性质
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | white to very dark brown |
溶解性 | DMSO: 2 mg/mL, clear |
储存温度 | 2-8℃ |
SMILES string | O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1 |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |