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MRS 1754 hydrate

品牌
Sigma-Aldrich
货号
M6316
规格纯度
≥98% (HPLC), solid
价格
3218.16 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
MRS 1754 hydrate
8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:

  • to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
  • blastema formation in zebrafish
  • to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

包装

5, 25 mg in glass bottle

生化/生理作用

MRS 1754 hydrate is ap-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.
MRS 1754 hydrate is a potent A2Badenosine receptor antagonist.

特点和优势

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Manufactured and sold under license from Adenosine Therapeutics LLC.

基本信息

经验(实验)分子式 C26H26N6O4· xH2O
分子量 486.52 (anhydrous basis)
MDL编号 MFCD11046004
PubChem化学物质编号 24278793
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
颜色 off-white
溶解性 DMSO: soluble >10 mg/mL
储存温度 room temp
SMILES string O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3
InChI 1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2
InChI key ZACJDWOPQROWIK-UHFFFAOYSA-N
Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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