MC2050 hydrate

半岛bd体育手机客户端 说明

应用

MC2050 hydrate may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C19H21N5OS·2HCl · xH2O
分子量	440.39 (anhydrous basis)
MDL编号	MFCD21608523
PubChem化学物质编号	329825234
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H2O: ≥5 mg/mL at warmed to 60 ℃
储存温度	2-8℃
SMILES string	O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
InChI	1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
InChI key	LMZZPRHHBPFDGE-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable