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L-655,708

品牌
Sigma-Aldrich
CAS
130477-52-0
货号
L9787
规格纯度
≥98% (HPLC), powder
价格
1306.9 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
130477-52-0
L-655,708
L-655708
Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.

包装

5, 25 mg in glass bottle

生化/生理作用

L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
Novel ligand selective for the benzodiazepine site of GABAAreceptors which contain the α5subunit.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C18H19N3O4
分子量 341.36
MDL编号 MFCD02684528
PubChem化学物质编号 24278527
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
溶解性 DMSO: ≥6.0 mg/mL (Warmed)
H2O: insoluble
创始人 Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES string CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12
InChI 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
InChI key YKYOQIXTECBVBB-AWEZNQCLSA-N
Gene Information human ... GABRA5(2558)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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