半岛bd体育手机客户端 说明
应用
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.
包装
5, 25 mg in glass bottle
生化/生理作用
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
Novel ligand selective for the benzodiazepine site of GABAAreceptors which contain the α5subunit.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
经验(实验)分子式 | C18H19N3O4 |
分子量 | 341.36 |
MDL编号 | MFCD02684528 |
PubChem化学物质编号 | 24278527 |
NACRES | NA.77 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
溶解性 | DMSO: ≥6.0 mg/mL (Warmed) H2O: insoluble |
创始人 | Merck & Co., Inc., Kenilworth, NJ, U.S. |
SMILES string | CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12 |
InChI | 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
InChI key | YKYOQIXTECBVBB-AWEZNQCLSA-N |
Gene Information | human ... GABRA5(2558) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |