半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).
基本信息
| 经验(实验)分子式 | C18H16N4O2S |
| 分子量 | 352.41 |
| PubChem化学物质编号 | 329825926 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | light yellow to dark yellow |
| 溶解性 | DMSO: 10 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O |
| InChI | 1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24) |
| InChI key | WCEDGRTWDSHZHF-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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