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KDS2010

品牌
Sigma-Aldrich
CAS
1894207-45-4
货号
SML2612
规格纯度
≥98% (HPLC)
价格
1276.87 *本价格含增值税费
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半岛bd体育手机客户端 名称:
1894207-45-4
KDS2010
(S)-2-((4′-(Trifluoromethyl)biphenyl-4-yl)methylamino)propanamide methanesulfonate
(S)-2-(((4′-Trifluoromethylbiphenyl-4-yl)methyl)amino)propanamide methanesulfonate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

KDS2010 is a highly selective, substrate-competitive, potent and reversible monoamine oxidase MAO-B inhibitor (IC50 = 7.6 nM/MAO-B vs >100 μM/MAO-A; little affinity toward 99 kinases and 84 non-kinase targets) with excellent ADME/Tox profiles (IC50 >10 μM/P450, >50 μM/hERG), brain permeability and oral availability ([rat F = 123.5%; 10 mg/kg p.o.). KDS2010 restores memory impairments in APP/PS1 mice following either short- or long-term treatment (3-d or 4-wk 10 mg/kg/day p.o.) without aberrant GABA levels observed with prolonged irreversible inhibition by selegiline (MAO-B/MAO-A IC50 = 10 nM/1.5 μM) due to compensatory diamine oxidase (DAO) induction.

基本信息

经验(实验)分子式 C17H17F3N2O · CH3SO3H
分子量 418.43

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 H2O: 2 mg/mL, clear
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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