J113863, cis isomer

品牌

Sigma-Aldrich

CAS

202796-41-6

货号

SML1977

包装型号

规格纯度

>97% (HPLC)

价格

1059.4 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

202796-41-6
J113863, cis isomer
1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Piperidinium, 1-(1-cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethyl-, iodide (1:1), cis-

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

J113863 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both J113863 and its enantiomer c exhibit low binding affinity toward CCR2 and CCR5 where they activate three G_iand two G₀protein isoforms. J113863 does not activate G₁₂protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

基本信息

经验(实验)分子式	C₃₀H₃₇Cl₂IN₂O₂
分子量	655.44
MDL编号	MFCD09971133

半岛bd体育手机客户端性质

测定	>97% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable