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位置: 首页> 品牌> Sigma-Aldrich> 7-Chloro-5-(2′-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one

ITH12575

品牌
Sigma-Aldrich
CAS
1802013-08-6
货号
SML1947
包装型号
规格纯度
≥98% (HPLC)
价格
973.81 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1802013-08-6
ITH12575
4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-
7-Chloro-5-(2′-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. At higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel that plays a key role in the neuronal electrical activity.

基本信息

经验(实验)分子式 C18H18ClNOS
分子量 331.86
MDL编号 MFCD30720887
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string CC(C)C1=C(C2C(C=C(Cl)C=C3)=C3NC(CS2)=O)C=CC=C1

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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