半岛bd体育手机客户端 说明
生化/生理作用
Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.
基本信息
| 经验(实验)分子式 | C22H34O7 |
| 分子量 | 410.50 |
| MDL编号 | MFCD00078929 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]/D -8 to -5°, c = 0.5 in chloroform-d |
| 颜色 | white to beige |
| 溶解性 | DMF:H2O (9:1): 2 mg/mL, clear |
| 储存温度 | ?20℃ |
| SMILES string | CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C |
| InChI | 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1 |
| InChI key | CLOQVZCSBYBUPB-VDCUXWMXSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H312 |
| 预防措施声明 | P280 - P302 + P352 + P312 - P362 + P364 - P501 |
| 危险分类 | Acute Tox. 4 Dermal |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
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