半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growthin vitroin tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
基本信息
| 经验(实验)分子式 | C18H16O4 |
| 分子量 | 296.32 |
| MDL编号 | MFCD12912419 |
| PubChem化学物质编号 | 329815315 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 储存条件 | desiccated |
| 颜色 | white to off-white |
| 溶解性 | DMSO: >20 mg/mL |
| 储存温度 | room temp |
| SMILES string | COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O |
| InChI | 1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+ |
| InChI key | BZCADTHMZLYKAR-MDWZMJQESA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H400 |
| 预防措施声明 | P273 |
| 危险分类 | Aquatic Acute 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
