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IMD-0354

品牌
Sigma-Aldrich
CAS
978-62-1
货号
I3159
规格纯度
≥98% (HPLC), solid
价格
2717.89 *本价格含增值税费
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半岛bd体育手机客户端 名称:
978-62-1
IMD-0354
N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.

包装

5, 10 mg in glass bottle
Light sensitive. Packaged under nitrogen.

生化/生理作用

IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells.In vivostudies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β.[4]

基本信息

经验(实验)分子式 C15H8ClF6NO2
分子量 383.67
MDL编号 MFCD00218820
PubChem化学物质编号 24724513
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
溶解性 DMSO: >20 mg/mL
运输 wet ice
储存温度 ?20℃
SMILES string Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
InChI 1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChI key CHILCFMQWMQVAL-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

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