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位置: 首页> 品牌> Sigma-Aldrich> IKK-16 dihydrochloride

IKK-16 dihydrochloride

品牌
Sigma-Aldrich
货号
SML1138
规格纯度
≥98% (HPLC)
价格
1746.67 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
IKK-16 dihydrochloride
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide dihydrochloride
IKK16 hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

IKK-16 dihydrochloride has been used as an nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor kinase inhibitor (IκB) in B220+ CKO or CreWT naive B cells. It has also been used as a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB inhibitor) in poly(I:C) transfection-induced retinoic acid-inducible gene (RIG-I), melanoma differentiation-associated gene 5 (MDA-5), and caspase-11 expressing mouse embryonic fibroblasts (MEFs).

包装

5, 25 mg in glass bottle

生化/生理作用

IKK-16 is a selective inhibitor of I K B kinase (IKK), part of the upstream NF- K B signal transduction cascade involved in the cellular response to inflammation. IKK-16 has IC50values of 40, 70 and 200 nM for IKKβ (IKK-2), IKK complex and IKKα (IKK-1) respectively. In a mouse sepsis model, IKK-16 reduced the multiple organ dysfunction, showing an antiinflammatory and endothelial protective effect likely mediated by inhibition of inflammation through NF- K B. IKK-16 has also been found to have some activity as an inhibitor of protein kinase D (PKD) and of multidrug resistance protein 1 (MDR1, ABCB1).

基本信息

经验(实验)分子式 C28H29N5OS · 2HCl
分子量 556.55
PubChem化学物质编号 329825674

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to beige
溶解性 DMSO: 20 mg/mL, clear
储存温度 ?20℃
SMILES string O=C(N1CCC(N2CCCC2)CC1)C3=CC=C(NC4=NC=CC(C5=CC(C=CC=C6)=C6S5)=N4)C=C3.C
InChI 1S/C28H29N5OS.CH4/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H4
InChI key YJGZKHHCMOHIFA-UHFFFAOYSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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