半岛bd体育手机客户端 名称：
105925-39-1
iHAP1
(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone
2-Chloro-10-(4-methoxybenzoyl)-10H-phenothiazine
半岛bd体育手机客户端 介绍：
半岛bd体育手机客户端 说明
生化/生理作用
iHAP1 is a potent activator of protein phosphatase 2A (PP2A) that allosterically facilitates assembly and activation of PP2A holoenzyme complex consisting PPP2R1A, PPP2R5E (B56ε, regulatory), and PPP2CA subunits. iHAP1 induces dephosphorylation of MYBL2 transcription factor on Ser241, causing irreversible cell cycle arrest of leukemia and other cancer cells in prometaphase. iHAP1 exhibits significant antitumor activity and lack of toxicity in T-ALL xenograft mice models. Normal CD34+ HSPCs are appears to be resistant to iHAP1. iHAP1 does not inhibit dopamine receptor D2.
基本信息
| 经验(实验)分子式 |
C20H14ClNO2S |
| 分子量 |
367.85 |
| MDL编号 |
MFCD01245092 |
半岛bd体育手机客户端 性质
| 质量水平 |
100 |
| 测定 |
≥98% (HPLC) |
| 形式 |
powder |
| 颜色 |
white to beige |
| 溶解性 |
DMSO: 2 mg/mL, clear |
| 储存温度 |
2-8℃ |
安全信息
| 储存分类代码 |
11 - Combustible Solids |
| WGK |
WGK 3 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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