半岛bd体育手机客户端 说明
生化/生理作用
GSK2795039 is a non-cytotoxic (100μM, 24 hrs, HEK293), NADPH-competitive, potent and selective NOX2 inhibitor (IC50/[NADPH] = 447 nM/25 μM, 2.29 μM/1 mM by NADPH depletion measurement; eNOS & NOX1/3/4/5 IC50>100 μM, PKCB II IC50>25 μM, xanthine oxidase IC50= 28.8 μM). GSK2795039 inhibits PMA-induced reactive oxygen species (ROS) production in cultures (IC50= 182 nM; HL60) and exhibitsin vivoefficacy against complete Freund′s adjuvant-induced paw inflammation (ED50= 2 mg/kg, ED100= 100 mg/kg ip.) as well as cerulein-induced acute pancreatitis (ED50= 100 mg/kg ip.) in mice.
基本信息
| 经验(实验)分子式 | C23H26N6O2S |
| 分子量 | 450.56 |
| MDL编号 | MFCD30489720 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | ?20℃ |
| SMILES string | O=S(NC1=C2C(N(C(C)C)C=C2C3=CC4=C(C=C3)CCN4C)=NC=C1)(C5=NN(C)C=C5)=O |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
