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GAT229

品牌
Sigma-Aldrich
CAS
889860-85-9
货号
SML1951
规格纯度
≥98% (HPLC)
价格
1225.94 *本价格含增值税费
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半岛bd体育手机客户端 名称:
889860-85-9
GAT229
S-(-)-3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

GAT229 is the S-(-)-enantiomer of GAT211, a positive allosteric modulator (PAM) of cannabinoid CB1 receptor signaling that was found to amplify the therapeutic effect of endocannabinoids without the negative side effects of psychoactivity or tolerance. GAT229 was found to be a potent, Gαi/o-biased CB1 PAM without intrinsic activity, while the R-(+)-enantiomer, GAT228, was found to be an unbiased CB1 allosteric agonist. In radioligand binding assays, both GAT228 and GAT229 behaved as PAMs of orthosteric ligand binding, with GAT229 exhibiting higher potency and efficacy. Allosteric CB1R activation by GAT211 and its enantiomers could be a better therapeutic strategy for enhancing endogenous cannabinergic activity than targeting endocannabinoid-degrading enzymes with small-molecule inhibitors, with a lower likelihood of tolerance and dependence.

基本信息

经验(实验)分子式 C22H18N2O2
分子量 342.39
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
旋光性 [α]/D -80 to -94°, c = 1 in methanol
颜色 white to beige
溶解性 DMSO: 20 mg/mL, clear
储存温度 2-8℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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