半岛bd体育手机客户端 说明

应用

Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.

包装

5, 25 mg in glass bottle

生化/生理作用

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

基本信息

经验(实验)分子式	C32H44O8
分子量	556.69
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
旋光性	[α]/D -60 to -75°, c = 0.7 (CDCl3)
颜色	white to beige
溶解性	DMSO: 15 mg/mL, clear
储存温度	?20℃
InChI	1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChI key	NDYMQXYDSVBNLL-MUYMLXPFSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable