半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
CP-863187 is a potent p38α (p38α) inhibitor (IC50= 5.8 nM) with 44-fold selectivity over p38β (p38β) and no inhibitory potency against p38γ (p38γ) and p38δ (p38δ) isoforms. CP-863187 effectively inhibits LPS-stimulated cellular TNF-α productionin vitro(IC50= 259 and 25 nM, using human whole blood and isolated mononuclear cells, respectively) and in ratsin vivo(ED50= 0.3 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 87%/dog, 40%/monkey, 30%/rat with 5 mg/kg oral dosage; F = 66%/rat with 50 mg/kg oral dosage).
法律信息
Sold for research purposes under agreement from Pfizer Inc.
基本信息
| 经验(实验)分子式 | C18H14F2N4O |
| 分子量 | 340.33 |
| MDL编号 | MFCD30480740 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 10 mg/mL, clear |
| 储存温度 | room temp |
| SMILES string | FC1=C(C2=C(OC=N2)C(C=C3)=CN4C3=NN=C4C(C)C)C=C(F)C=C1 |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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