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CK-869

品牌
Sigma-Aldrich
CAS
388592-44-7
货号
C9124
规格纯度
≥98% (HPLC)
价格
1453.88 *本价格含增值税费
促销
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半岛bd体育手机客户端 名称:
388592-44-7
CK-869
CK-0157869
CK 869
2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

CK-869 has been used as an Arp2/3 complex inhibitor:

  • to treat cultured mammalian cells and study itsin vitroandin vivoeffects on microtubule assembly
  • to induce membrane blebbing in HT1080 fibrosarcoma cells
  • to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

包装

5, 25 mg in glass bottle

生化/生理作用

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

基本信息

经验(实验)分子式 C17H16BrNO3S
分子量 394.28
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to light gray
溶解性 DMSO: 10 mg/mL, clear
储存温度 2-8℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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