半岛bd体育手机客户端 说明
应用
CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
包装
5, 25 mg in glass bottle
生化/生理作用
CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.
CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50= 70 nM).
特点和优势
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C22H23N3O2S |
| 分子量 | 393.50 |
| MDL编号 | MFCD00948114 |
| PubChem化学物质编号 | 329825216 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white to tan |
| 溶解性 | DMSO: ≥10 mg/mL |
| 创始人 | Pfizer |
| 储存温度 | 2-8℃ |
| SMILES string | Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2 |
| InChI | 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26) |
| InChI key | VPTONMHDLLMOOV-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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