半岛bd体育手机客户端 说明
生化/生理作用
cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2+influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).
基本信息
| 经验(实验)分子式 | C22H29N3· 2CF3CO2H |
| 分子量 | 563.53 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | H2O: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
