半岛bd体育手机客户端 说明
应用
CID755673 was used to study the role of PKD in dendrite retraction in mouse Purkinje cells.
包装
5, 25 mg in glass bottle
生化/生理作用
CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1 (PKCμ), PKD2, and PKD3 (PKCν). CID755673 is not competitive with ATP.
CID755673 was not suitable to inhibit PKD in Swiss 3T3 cells as it utilizes PKD-dependent pathway to enhance the mitogenic signaling triggered by EGF, phorbol esters and bombesin. It should, therefore, be used with caution.
特点和优势
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C12H11NO3 |
| 分子量 | 217.22 |
| MDL编号 | MFCD03828155 |
| PubChem化学物质编号 | 329825080 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to tan |
| 溶解性 | DMSO: ≥15 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Oc1ccc2oc3C(=O)NCCCc3c2c1 |
| InChI | 1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15) |
| InChI key | AACFPJSJOWQNBN-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
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