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CBIQ

品牌
Sigma-Aldrich
CAS
32081-28-0
货号
C6617
规格纯度
≥98% (HPLC), solid
价格
2410.17 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
32081-28-0
CBIQ
4-Chlorobenzo[f]isoquinoline
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

特点和优势

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C13H8NCl
分子量 213.66
MDL编号 MFCD02179769
PubChem化学物质编号 24724450
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
颜色 off-white
溶解性 DMSO: 15 mg/mL
SMILES string Clc1nccc2c1ccc3ccccc23
InChI 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
InChI key SHQLTRRYZVBEMR-UHFFFAOYSA-N

安全信息

象形图 GHS05GHS06
警示用语: Danger
危险声明 H301 - H315 - H318 - H335
预防措施声明 P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
危险分类 Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

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