半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
BIMU8 hydrate is a potent 5-HT4serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT4receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT4, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT4to somatic but not dendritic regions of CA1 pyramidal neurons.
基本信息
| 经验(实验)分子式 | C19H26N4O2·HCl · xH2O |
| 分子量 | 378.90 (anhydrous basis) |
| PubChem化学物质编号 | 329773228 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 储存条件 | desiccated |
| 颜色 | off-white to light tan |
| 溶解性 | H2O: ≥5 mg/mL |
| 储存温度 | 2-8℃ |
| InChI | 1S/C19H26N4O2.ClH.H2O/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H;1H2/t13-,14+,15-;; |
| InChI key | HZJJVFOOACXPTH-XZAJHMFNSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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