BD 1063 dihydrochloride

半岛bd体育手机客户端 说明

应用

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

• to study thein vitroandin vivoprotective action of S1R against ferroptosis in hepatocellular carcinoma cells
• in a comparative evaluation of its anti-hyperalgesic action with that of the effects ofN-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
• to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

包装

5, 25 mg in glass bottle

生化/生理作用

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

其他说明

air sensitive

基本信息

经验(实验)分子式	C13H18Cl2N2· 2HCl
分子量	346.12
MDL编号	MFCD00792740
PubChem化学物质编号	329825284
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	H2O: >15 mg/mL
储存温度	room temp
SMILES string	Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2
InChI	1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChI key	NXFDBTLQOARIMH-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable