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位置: 首页> 品牌> Sigma-Aldrich> Δ4-abiraterone

Abiraterone D4A metabolite

品牌
Sigma-Aldrich
CAS
154229-21-7
货号
SML1963
规格纯度
≥98% (HPLC)
价格
1225.94 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
154229-21-7
Abiraterone D4A metabolite
17-(3-Pyridinyl)-androsta-4,16-dien-3-one
Δ4-abiraterone
D4-abiraterone
Abiraterone ketone analog
D4A
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

D4A (Δ4-Abiraterone; 3-Pyridinyl)-androsta-4,16-dien-3-one) is an abiraterone metabolite found to be more active than abiraterone. Abiraterone is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17 alpha hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition can stop the production of androgens in both places. It is approved for the treatment of metastatic castration-resistant prostate cancer. D4A blocks not only CYP17A1, but also blocks two other enzymes, 3?-hydroxysteroid dehydrogenase (3?HSD) and steroid-5?-reductase (SRD5A), which are involved in producing the androgen 5?-dihydrotestosterone (DHT), while also blocking the androgen receptor.

基本信息

经验(实验)分子式 C24H29NO
分子量 347.49

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 10 mg/mL, clear
储存温度 2-8℃
InChI 1S/C24H29NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-4,7,13-15,19,21-22H,5-6,8-12H2,1-2H3/t19-,21-,22-,23-,24+/m0/s1
InChI key GYJZZAJJENTSTP-NHFPKVKZSA-N

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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