A1120

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.

基本信息

经验(实验)分子式	C20H19F3N2O3
分子量	392.37
MDL编号	MFCD12912393
PubChem化学物质编号	329770816
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	off-white
溶解性	DMSO: ≥10 mg/mL
储存温度	2-8℃
SMILES string	OC(=O)c1ccccc1NC(=O)N2CCC(CC2)c3ccccc3C(F)(F)F
InChI	1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
InChI key	MEAQCLPMSVEOQF-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H317 - H319 - H400
预防措施声明	P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable