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A-33

品牌
Sigma-Aldrich
CAS
915082-52-9
货号
SML2121
规格纯度
≥98% (HPLC)
价格
1465.19 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
915082-52-9
A-33
4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-4-pyrimidinyl]amino]-benzeneacetic acid
2-(4-{[2-(5-Chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid
2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
A33
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

A-33 (A33) is a potent and selective catalytic site-targeting PDE4B inhibitor (IC50 = 15 nM/PDE4B vs. 1.7 μM/PDE4D) that effectively prevents PDE4B-medicated cellular cAMP hydrolysis (150%/320% increased cAMP level with 100 nM/1 μM A-33 pre-treament in murine hippocampal HT-22 cells following 10 nM isoproterenol stimulation)in vitroand inhibits LPS-induced TNF-α production in micein vivo(ID50 = 14 mg/kg p.o.). When administered via intraperitoneal injection, A-33 improves cognitive function in a rat model of traumatic brain injury (0.3 mg/kg i.p.) and exhibits antidepressant property in mice (0.3-1 mg/kg i.p.)in vivo.

基本信息

经验(实验)分子式 C19H18ClN3O2S
分子量 387.88
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string O=C(O)CC1=CC=C(NC2=NC(C3=CC=C(Cl)S3)=NC(C)=C2CC)C=C1

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3

Sigma-Aldrich

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