16:0(2R-OH) Ceramide

半岛bd体育手机客户端 说明

一般描述

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration.

生化/生理作用

Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.

包装

5 mL Amber Glass Screw Cap Vial (860815P-5mg)
5 mL Amber Glass Screw Cap Vial (860815P-25mg)

基本信息

经验(实验)分子式	C34H67NO4
分子量	553.90
NACRES	NA.25

半岛bd体育手机客户端 性质

形式	powder
包装	pkg of 1 × 25 mg (860815P-25mg) pkg of 1 × 5 mg (860815P-5mg)
manufacturer/tradename	Avanti Polar Lipids 860815P
运输	dry ice
储存温度	?20℃
SMILES string	CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3