(R)-ZINC-3573

品牌

Sigma-Aldrich

货号

SML1699

包装型号

规格纯度

≥98% (HPLC)

价格

1562.86 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

(R)-ZINC-3573
( R)-ZINC72453573
(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

包装

5, 25 mg in glass bottle

生化/生理作用

(R)-ZINC-3573 is a selective agonist probe of the orphan receptor Mas-related G-protein coupled receptor member X2 (MRGPRX2), a G-protein coupled receptor (GPCR) selectively expressed in mast cells and dorsal root and trigeminal ganglia primary sensory neurons of primates. Lack of selective and potent probes has made it difficult to determine MRGPRX2 funtion. (R)-ZINC-3573 was shown to be a potent and selective agonist with an EC₅₀value of 760 nM for MRGPRX2 and little activity for MRGPRX1 or over 350 other GPCRs and 97 kinases tested. (R)-ZINC-3573 activates endogenous MRGPRX2 expressed in a human mast cell line and induced degranulation and calcium release.

基本信息

经验(实验)分子式	C₁₈H₂₁N₅
分子量	307.39

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	CN([C@H](CC1)CN1C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)C

安全信息

象形图
警示用语：	Warning
危险声明	H315
危险分类	Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable