2-氟肾上腺素-9-β-<SC>D</SC>-阿拉伯呋喃糖苷

2-氟肾上腺素-9-β- D -阿拉伯呋喃糖苷

品牌

Sigma-Aldrich

CAS

21679-14-1

货号

F2773

包装型号

规格纯度

DNA synthesis and methylation inhibitor

价格

1968.86 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

21679-14-1
2-Fluoroadenine-9-β- D -arabinofuranoside
9-β- D -Arabinofuranosyl-2-fluoroadenine
F-ara-A
Fludarabine des-phosphate
2-氟肾上腺素-9-β- D -阿拉伯呋喃糖苷

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

应用

2-Fluoroadenine-9-β- D -arabinofuranoside (F-ara-A) has been used:

to assess its interaction with kinase inhibitor UCN-01 in human leukemia cells (U937 and HL-60) and primary patient samples
to assess its influence on endothelial cells by apoptosis assay and human microvascular endothelial cells (HMECs) by cytotoxicity assay
in comparative cytotoxicity studies with Alemtuzumab CDC in 17p13- chronic lymphocytic leukemia (CLL) patients

包装

5, 10 mg in glass bottle

生化/生理作用

Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences.

警告

The name fludarabine refers to 9-β- D -arabinofuranosyl-2-fluoroadenine 5′-phosphate, but is sometimes erroneously used for this compound, which lacks the phosphate.

基本信息

经验(实验)分子式	C₁₀H₁₂FN₅O₄
分子量	285.23
Beilstein	1225932
EC 号	244-525-5
MDL编号	MFCD00132942
PubChem化学物质编号	24894830
NACRES	NA.77

半岛bd体育手机客户端性质

质量水平	200
储存温度	2-8℃
SMILES string	Nc1nc(F)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
InChI	1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
InChI key	HBUBKKRHXORPQB-FJFJXFQQSA-N
Gene Information	human ... ADORA3(140) rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

安全信息

象形图
警示用语：	Warning
危险声明	H341 - H361d
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Muta. 2 - Repr. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves